HCID 59840903, compound → {4-[6-(2-Ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-methanesulfonamide

HRID 1941916Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][S:9]([NH-:12])(=[O:11])=[O:10])=[CH:4][CH:3]=1.Cl[C:14]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[O:26][CH2:27][CH3:28])[N:17]=[CH:16][N:15]=1>CN(C=O)C>[CH2:27]([O:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:18]1[N:17]=[CH:16][N:15]=[C:14]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][S:9]([NH2:12])(=[O:10])=[O:11])=[CH:4][CH:3]=2)[CH:19]=1)[CH3:28]

Participants

Conditions

Temperature: 80 °C

Procedure

A mixture of (4-aminophenyl)methanesulfonyl amide (0.093 g, 0.50 mmol) and 4-chloro-6-(2-ethoxyphenyl)-pyrimidine (0.117 g, 0.50 mmol) in DMFA (3 mL) was stirred at 80° C. till the reaction completion (TLC control). Then the reaction mixture was concentrated in vacuo and the residue recrystallized from isopropanol to give {4-[6-(2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-methanesulfonamide (Compound 6)

Workup

concentrationThen the reaction mixture was concentrated in vacuo
customthe residue recrystallized from isopropanol

Sources & evidence

ORD record: ord-fca71bb288ed40be917302b47130659e
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389521B2

Reaction notes

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