Trifluoroacetic acid → Molidustat

HRID 1942030Notes

Reaction equation

HRID 1942030 reaction equation
C(O[C:4](=[O:15])[C:5]([N:10]1[CH:14]=[CH:13][N:12]=[N:11]1)=[CH:6][N:7](C)C)C.[NH:16]([C:18]1[N:23]=[CH:22][N:21]=[C:20]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[CH:19]=1)N.C(O)(C(F)(F)F)=O>C(OCC)(=O)C>[N:24]1([C:20]2[N:21]=[CH:22][N:23]=[C:18]([N:16]3[C:4](=[O:15])[C:5]([N:10]4[CH:14]=[CH:13][N:12]=[N:11]4)=[CH:6][NH:7]3)[CH:19]=2)[CH2:25][CH2:26][O:27][CH2:28][CH2:29]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 13393622(6-Morpholin-4-ylpyrimidin-4-yl)hydrazineHCID 66726233Ethyl 3-(dimethylamino)-2-(1H-1,2,3-triazol-1-yl)acrylate

Product 1

HCID 59603622MolidustatYield 61.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
5 °C

Procedure

1.9 g (8.8 mmol) of the compound from Example 3A and 1.9 g (9.7 mmol) of the compound from Example 16A are initially introduced into 25 ml ethyl acetate and 504 mg (4.4 mmol) TFA are added at RT. The mixture is stirred under reflux for 16 h, then cooled to 5° C. and subsequently stirred for a further 2 h. The solid formed is filtered off, washed with ethyl acetate and dried first in air and thereafter under a high vacuum. 1.7 g of product are obtained.

Workup

  1. additionare added at RT
  2. temperatureunder reflux for 16 h
  3. stirringsubsequently stirred for a further 2 h
  4. customThe solid formed
  5. filtrationis filtered off
  6. washwashed with ethyl acetate
  7. customdried first in air

Sources & evidence

ORD record
ord-a616bb5b70134848b8fe0817f51adf9f
Source dataset
uspto-grants-2013_03
Patent number
US08389520B2

Reaction notes

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