反应详情

5.0 g (22.9 mmol) of ethyl 2-oxo-1,2-dihydroquinoxaline-3-carboxylate, 3.8 g (27.5 mmol) of potassium carbonate, 4.56 g (27.5 mmol) of potassium iodide and 2.43 g (25.2 mmol) of chloromethyl methyl sulfide were dissolved in acetone (100 mL), and the solution was refluxed for 5 hours. After completion of the reaction, the solvent was distilled off under reduced pressure, and to the residue thus obtained, a mixture of water and ethyl acetate was added. The resulting mixture was separated. The organic layer was dried over anhydrous magnesium sulfate, and the inorganic matter was separated by filtration. The solvent was distilled off under reduced pressure, and the residue thus obtained was solidified using diethyl ether, to obtain 3.5 g (yield: 55%) of ethyl 1-(methylthiomethyl)-2-oxo-1,2-dihydroquinoxaline-3-carboxylate as a white powder.

1. temperaturethe solution was refluxed for 5 hours
2. customAfter completion of the reaction
3. distillationthe solvent was distilled off under reduced pressure
4. customto the residue thus obtained
5. additionwas added
6. customThe resulting mixture was separated
7. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
8. customthe inorganic matter was separated by filtration
9. distillationThe solvent was distilled off under reduced pressure
10. customthe residue thus obtained