反应详情

温度

65 °C

2-Methanesulfonyl-5-phenylethynyl-pyrimidine (100 mg, 3.11 mmol), cyclopentylamine (80 μl, 6.22 mmol) and Et3N (110 μl, 6.22 mmol) were suspended in 1 ml THF and stirred for 1 hour at 65° C. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography by directly loading the crude material onto a silica gel column and eluting with (heptane:ethyl acetate 100:0→0:100). The desired compound was obtained as a white solid (85 mg, 83%), MS: m/e=264.2 (M+H+).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue was purified by flash chromatography
3. washeluting with (heptane:ethyl acetate 100:0→0:100)