反应详情

温度

50 °C

A mixture of 34.6 mg (0.128 mmol) 2-(4-Cyclopropyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, 23 mg (0.192 mmol) 2-phenyl-oxirane and 38 mg (0.384 mmol) NEt3 in 2 mL DCM were stirred at 50° C. for 2 h and concentrated. The residue was taken up in methanol and subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and NEt3. The product containing fractions were evaporated to yield 7.1 mg (14%) of the title compound. MS m/e: 391.4 [M+H]+.

1. concentrationconcentrated
2. customsubjected to purification by preparative HPLC on reversed phase
3. washeluting with a gradient
4. customformed from acetonitrile, water and NEt3
5. additionThe product containing fractions
6. customwere evaporated