反应详情

2.69 g (15 mmol) of benzothiazole-6-carboxylic acid is dissolved in a mixture of 1.34 g (15 mmol) 4-amino-butan-1-ol and 70 mL dry tetrahydrofuran. 2.43 g (15 mmol) of CDI is added after stirring for 30 minutes and then stirred for another hour. The mixture is concentrated in vacuum. The resulting residue is suspended in dichloromethane, water is added, and the organic phase is separated. The aqueous phase is extracted with dichloromethane twice. The combined organic phases are dried over sodium sulfate and concentrated in vacuum.

1. stirringstirred for another hour
2. concentrationThe mixture is concentrated in vacuum
3. additionwater is added
4. customthe organic phase is separated
5. extractionThe aqueous phase is extracted with dichloromethane twice
6. dry with materialThe combined organic phases are dried over sodium sulfate
7. concentrationconcentrated in vacuum