Acetic Acid → HCID 87210797, compound

HRID 1942394Notes

Reaction equation

HRID 1942394 reaction equation
C([O:3][CH:4](OCC)[CH2:5][CH2:6][CH2:7][NH:8][C:9]([C:11]12[CH2:20][CH:15]3[CH2:16][CH:17]([CH2:19][CH:13]([CH2:14]3)[CH2:12]1)[CH2:18]2)=[O:10])C.C(O)(=O)C.Cl>C(O)C>[O:3]=[CH:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([C:11]12[CH2:18][CH:17]3[CH2:19][CH:13]([CH2:14][CH:15]([CH2:16]3)[CH2:20]1)[CH2:12]2)=[O:10]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 66937514HCID 66937514, compound

Product 1

HCID 87210797HCID 87210797, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.94 g (6 mmol) N-(4,4-diethoxybutyl)adamantylcarboxamide, 7.5 mL of acetic acid, 3.75 mL of 1N aqueous hydrochloric acid and 30 mL ethanol are put together and stirred for 16 hours under argon atmosphere. Ethanol is evaporated. Then the resulting residue is dispersed in dichloromethane and extracted with saturated sodium bicarbonate solution. The organic phase is dried with sodium sulfate and the solvent evaporated in vacuum.

Workup

  1. customEthanol is evaporated
  2. additionThen the resulting residue is dispersed in dichloromethane
  3. extractionextracted with saturated sodium bicarbonate solution
  4. dry with materialThe organic phase is dried with sodium sulfate
  5. customthe solvent evaporated in vacuum

Sources & evidence

ORD record
ord-18ee0bc755d04a2abd79812962b1bdbe
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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