反应详情

温度

80 °C

1.55 g of 2,3-dihydro-1H-indolizinium chloride and 1.59 g of 1-methylindole-3-carboxaldehyde were suspended in 15 ml of isopropanol, in a 50 ml three-necked flask. The reaction mixture was heated at 80° C. and then 820 μl of pyrrolidine were introduced. The reaction mixture was immediately cooled to ambient temperature. The precipitate was filtered off, and washed with 2 times 30 ml of isopropanol before being dried under a strong vacuum in the presence of P2O5, until a constant weight was obtained. 2.59 g of orange powder were recovered. The analyses (NMR) (d6-DMSO) and mass spectrometry ESI+M/Z=261) were in conformity with the expected structure.

1. temperatureThe reaction mixture was immediately cooled to ambient temperature
2. filtrationThe precipitate was filtered off
3. washwashed with 2 times 30 ml of isopropanol
4. dry with materialbefore being dried under a strong vacuum in the presence of P2O5, until a constant weight
5. customwas obtained
6. custom2.59 g of orange powder were recovered