反应详情

A solution of 395 mg (2 mmol) propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amine and 781 mg (3 mmol) 5-oxo-5-(4-phenylpiperazin-1-yl)pentanal in 1,2-dichloroethane (20 mL) is stirred for about 30 minutes. Then 0.75 g (3 mmol) of sodium triacetoxyborohydride is added and the mixture is stirred overnight. After hydrolysation with 30 mL of 1N aqueous NaOH solution the organic phase is separated, dried over sodium sulfate and concentrated in vacuum. The crude product obtained is purified via column chromatography on silica gel.

1. customAfter hydrolysation with 30 mL of 1N aqueous NaOH solution the organic phase is separated
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated in vacuum