反应详情

温度

70 °C

To a solution of 5-(3-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazol-5-yl)-2-(2-methylpropyl)benzonitrile (D61) (500 mg) in tetrahydrofuran (THF) (20 mL) stirred under nitrogen at room temperature was added 2M hydrochloric acid (1.239 mL). The reaction mixture was stirred at 70° C. for 2 h. After cooling the reaction, the solution was condensed under reduced pressure to give 5-{3-[2-ethyl-3-(2-oxoethyl)phenyl]-1,2,4-thiadiazol-5-yl}-2-(2-methylpropyl)benzonitrile (D62) (483 mg), which was used directly in the next step without further purification. MS (ES): C23H23N3OS requires 389. found 390.1 (M+H+).

1. temperatureAfter cooling
2. customthe reaction
3. customcondensed under reduced pressure