反应详情

温度

70 °C

To a solution of 3-chloro-5-(3-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazol-5-yl)-2-[(1-methylethyl)oxy]pyridine (D110) (2 g, 4.81 mmol) in Tetrahydrofuran (50 mL) was added HCl (4.81 mL, 9.62 mmol). The resulted solution was heated to 70° C. for 2 h. THF was removed in vacuo to afford [3-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]acetaldehyde (D111) (2 g, 4.98 mmol, 103% yield) as a crude product, which was used directly without further purification. MS (ES): C20H20ClN3O2S requires 401.0. found 402.0 (M+H+).

1. customTHF was removed in vacuo