反应详情

温度

90 °C

To a solution of [2-ethyl-3-({3-[(methyloxy)carbonyl]-1-azetidinyl}methyl)phenyl]boronic acid (2.2 g, 7.94 mmol)) in 1,4-dioxane (18 mL) and water (6 mL) were added 2-bromo-5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazole (3.18 g, 9.53 mmol), Pd2(dba)3 (0.582 g, 0.635 mmol), potassium carbonate (3.29 g, 23.82 mmol) and X-Phos (0.454 g, 0.953 mmol). The mixture was heated to 90° C. and stirred for 7 hours 11 mins. LCMS showed that the boronic acid was almost consumed completely. The heating was stopped and the solution was cooled to rt. The solution was filtered with celite and washed with EtOAc. The filtrate was concentrated under the reduced pressure. The residue was dissolved in EtOAc (50 mL) then washed with NaOH (30 mL, 1.0 M), organic phase was concentrated under reduced pressure. 50 mL TBME and 50 mL HCl (1.0 M) were added to the above residue and the obtained mixture was stirred at rt for 30 min. The yellow solid was collected by filtering. The yellow solid was stirred in TBME (50 mL) for 30 min at rt. 1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)-3-(methoxycarbonyl)azetidin-1-ium chloride (1.06 g) was collected by filtering and drying in vacuum as grey solid. δH (DMSO-d6, 600 MHz): 1.09 (3H, t), 1.33 (6H, m), 2.92 (2H, m), 3.72 (3H, m), 4.31 (4H, m), 4.58 (1H, m), 4.64 (1H, d), 4.84 (1H, dt), 7.39 (1H, m), 7.47 (1H, t,) 7.66 (1H, d), 7.72 (1H, d), 7.97 (1H, d), 8.10 (1H, s), 10.92 (1H, dd), 11.16 (1H, m).

1. customwas almost consumed completely
2. temperaturethe solution was cooled to rt
3. filtrationThe solution was filtered with celite
4. washwashed with EtOAc
5. concentrationThe filtrate was concentrated under the reduced pressure
6. dissolutionThe residue was dissolved in EtOAc (50 mL)
7. washthen washed with NaOH (30 mL, 1.0 M), organic phase
8. concentrationwas concentrated under reduced pressure
9. addition50 mL TBME and 50 mL HCl (1.0 M) were added to the above residue
10. stirringthe obtained mixture was stirred at rt for 30 min
11. customThe yellow solid was collected
12. filtrationby filtering
13. stirringThe yellow solid was stirred in TBME (50 mL) for 30 min at rt
14. custom1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)-3-(methoxycarbonyl)azetidin-1-ium chloride (1.06 g) was collected
15. filtrationby filtering
16. customdrying in vacuum as grey solid