4-Chloro-N-methylbenzenamine → HCID 45139098, compound

HRID 1942889Notes

Reaction equation

HRID 1942889 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH:9]([CH3:11])[CH3:10])[N:5]=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20]3)=[C:15]([O:25][CH3:26])[CH:14]=2)[N:3]=1.[Cl:27][C:28]1[CH:35]=[CH:34][C:31]([NH:32][CH3:33])=[CH:30][CH:29]=1>C(OCC)(=O)C>[Cl:27][C:28]1[CH:35]=[CH:34][C:31]([N:32]([CH3:33])[C:2]2[N:3]=[C:4]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([N:19]4[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20]4)=[C:15]([O:25][CH3:26])[CH:14]=3)[N:5]=[C:6]([O:8][CH:9]([CH3:11])[CH3:10])[N:7]=2)=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 702724-Chloro-N-methylbenzenamineHCID 86640785HCID 86640785, compound

Product 1

HCID 45139098HCID 45139098, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared from (4-chloro-6-isopropoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine and 4-chloro-N-methyl aniline in analogy to example 1c. Chromatography on Si—NH2 gel (Isolute) using ethyl acetate as an eluent gave the title compound as a colorless solid in 27% yield.

Sources & evidence

ORD record
ord-99cdf4addcc14fdbbb335c8b20ff8796
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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