反应详情

A solution of (4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine (0.35 g, 1.0 mmol) in a mixture of 7 ml methanol and 3.5 ml ethyl acetate was treated with triethylamine (0.21 ml, 1.5 mmol) and tris(dibenzylideneacetone) dipalladium dichloromethane-complex (70 mg, 0.09 mmol). The mixture was transferred to an autoclave, flushed with carbon monoxide and hold 20 hours at 80° C. under a pressure of 5 bar of carbon monoxide. After cooling and evacuating the carbon monoxide, the mixture was concentrated to about 2 ml and diluted again with a mixture of ethyl acetate/methanol 9:1 v/v. The title compound precipitated as an intensely yellow solid after cooling in the refrigerator for 17 hours. Yield=55%.

1. customflushed with carbon monoxide
2. temperatureAfter cooling
3. customevacuating the carbon monoxide
4. concentrationthe mixture was concentrated to about 2 ml
5. additiondiluted again with a mixture of ethyl acetate/methanol 9:1 v/v
6. customThe title compound precipitated as an intensely yellow solid
7. temperatureafter cooling in the refrigerator for 17 hours