反应详情

A solution of 3-fluoro-1,2-benzenediol (5.278 g, 41.2 mmol) in DMF (50 ml) was treated with potassium carbonate (17.08 g, 124 mmol) and 1,2-dibromoethane (3.91 ml, 45.3 mmol) and stirred at rt for 72 h. The reaction was treated with water (200 ml) and extracted 3×200 ml (EtOAc). The combined organic extracts were washed with water (200 ml), brine (200 ml), dried (MgSO4), evaporated and chromatographed (0-20% EtOAc-Cyclohexane) to give product as a clear oil. (2.437 g, 38%).

1. extractionextracted 3×200 ml (EtOAc)
2. washThe combined organic extracts were washed with water (200 ml), brine (200 ml)
3. dry with materialdried (MgSO4)
4. customevaporated
5. customchromatographed (0-20% EtOAc-Cyclohexane)
6. customto give product as a clear oil