反应详情

In a 25 ml flask, (3,5-dibromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (100 mg, 0.24 mmol) was dissolved in N,N-dimethyl formamide (2.4 ml), and potassium carbonate (37 mg, 0.266 mmol) was added thereto dropwise at room temperature. After stirring at room temperature for 10 minutes, bromo-methyl acetate was added dropwise and then stirred for 40 minutes at room temperature. The reaction mixture was filtered on celite and evaporated under reduced pressure. The residue was purified by column chromatography on silica eluting with a solvent of dichloromethane:methanol=20:1 to obtain the target compound 24 as white foam (48 mg, 41.0%).

1. customdropwise at room temperature
2. stirringstirred for 40 minutes at room temperature
3. filtrationThe reaction mixture was filtered on celite
4. customevaporated under reduced pressure
5. customThe residue was purified by column chromatography on silica eluting with a solvent of dichloromethane