反应详情

In a 25 ml flask, (3,5-dibromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (510 mg, 1.23 mmol) and tetrahydrofuran (40 ml) were added and stirred at 750 for 20 minutes. 4.0M Hydrochloric acid dissolved in 1,4-dioxane (0.34 ml, 1.36 mmol) was added thereto dropwise and then stirred at 75□ for 10 minutes. The reaction mixture was filtered in hot state without cooling and washed with ether, and the resulting solid was dried under vacuum at 600 for 12 hours to obtain the target compound 33 as white solid (520 mg, 93.7%).

1. additionwas added
2. stirringdropwise and then stirred at 75□ for 10 minutes
3. filtrationThe reaction mixture was filtered in hot state
4. temperaturewithout cooling
5. washwashed with ether
6. customthe resulting solid was dried under vacuum at 600 for 12 hours