反应详情

In a 25 ml flask, 3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine (370 mg, 2.72 mmol) and 4-methoxy-benzenesulfonyl chloride (618 mg, 2.99 mmol) were dissolved in dichloromethane (10 ml). Triethylamine (0.45 ml, 3.23 mmol) was added thereto and then stirred at room temperature for 2 hours. After neutralizing with 1N hydrochloric acid solution, the mixture was extracted with dichloromethane, and the combined organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica eluting with a solvent of dichloromethane. The fractions containing the product were collected and evaporated to obtain pale-green solid (700 mg, 84.1%).

1. extractionthe mixture was extracted with dichloromethane
2. dry with materialthe combined organic layer was dried over anhydrous sodium sulfate (Na2SO4)
3. filtrationfiltered
4. customevaporated under reduced pressure
5. customThe residue was purified by column chromatography on silica eluting with a solvent of dichloromethane
6. additionThe fractions containing the product
7. customwere collected
8. customevaporated