Piperazine → HCID 44608383, compound

HRID 1943685Notes

Reaction equation

HRID 1943685 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]([N:13]2[CH2:18][CH2:17][O:16][C:15]3[CH:19]=[N:20][CH:21]=[CH:22][C:14]2=3)=[O:12])[CH:5]=[C:6]([Cl:10])[C:7]=1[O:8]C.[Cl-].[Li+].N1CCNCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]([N:13]2[CH2:18][CH2:17][O:16][C:15]3[CH:19]=[N:20][CH:21]=[CH:22][C:14]2=3)=[O:12])[CH:5]=[C:6]([Cl:10])[C:7]=1[OH:8]

Participants

4

Reactant 3

HCID 4837PiperazineHCID 433294Lithium ChlorideHCID 66936568HCID 66936568, compound

Product 1

HCID 44608383HCID 44608383, compoundYield 47%

Procedure

By the same method as in Example 39, (3,5-dichloro-4-methoxy-phenyl)-(2,3-dihydro-pyrido[3,4-b][1,4]oxazin-1-yl)-methanone (100 mg, 0.29 mmol), lithium chloride (124 mg, 2.9 mmol) and piperazine (38 mg, 0.44 mmol) were reacted. The resulting solid was purified by recrystallizing from methanol to obtain the target compound 41 as pale-brown solid (40 mg, 47%).

Workup

  1. customThe resulting solid was purified
  2. customby recrystallizing from methanol

Sources & evidence

ORD record
ord-d4faae4269b54dcd8c89c336d33087ae
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

Loading…