反应详情

By the same method as in the step f) of Example 22, 1-(3,5-dibromo-4-methoxy-benzoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-carbonitrile (12 mg, 0.026 mmol) was reacted with lithium bromide (LiBr) (4.62 mg, 0.053 mmol) and piperazine (3.4 mg, 0.0399 mmol) to obtain the target compound 47-2, i.e., 1-(3,5-dibromo-4-hydroxy-benzoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-carbonitrile as white solid (9 mg, 78%).