反应详情

温度

20 °C

To a solution of 7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione) (10.52 g, 54.7 mmol) in anhydrous DMF (60 ml) was added NCS (8.04 g, 60.2 mmol). The reaction mixture was left to stir under nitrogen at 20° C. for 6 hours. The reaction mixture was concentrated in vacuo to give an amber oil. MeOH was added and left to stand for 18 hours. The resulting residue was filtered and dried under vacuum to give the title compound (7.69 g, 62%). m/z 227.2[MH+].

1. waitThe reaction mixture was left
2. concentrationThe reaction mixture was concentrated in vacuo
3. customto give an amber oil
4. waitleft
5. waitto stand for 18 hours
6. filtrationThe resulting residue was filtered
7. customdried under vacuum