Hydrochloric Acid → HCID 58147584, compound

HRID 1944117Notes

Reaction equation

HRID 1944117 reaction equation
C([O:3][C:4](=[O:35])[CH2:5][O:6][C:7]1[CH:16]=[C:15]2[C:10]([CH2:11][CH2:12][N:13]3[C:19]([C:20](=[O:27])[N:21]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH3:22])=[CH:18][C:17]([C:28]4[S:29][CH:30]=[CH:31][CH:32]=4)=[C:14]32)=[CH:9][C:8]=1[O:33][CH3:34])C.[OH-].[K+].Cl>C(O)C.O>[C:23]([N:21]([CH3:22])[C:20]([C:19]1[N:13]2[CH2:12][CH2:11][C:10]3[C:15]([C:14]2=[C:17]([C:28]2[S:29][CH:30]=[CH:31][CH:32]=2)[CH:18]=1)=[CH:16][C:7]([O:6][CH2:5][C:4]([OH:35])=[O:3])=[C:8]([O:33][CH3:34])[CH:9]=3)=[O:27])([CH3:25])([CH3:26])[CH3:24]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 58147668HCID 58147668, compound

Product 1

HCID 58147584HCID 58147584, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
78 °C

Procedure

A mixture of the product of example 63 (150 mg) and solid KOH (51 mg) in ethanol (5 ml) and water (5 ml) was stirred at 78° C. for 1 h. At room temperature, the reaction mixture was acidified with an aqueous HCl solution (1.0 M) until pH=1-2 and extracted with dichloromethane. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated in vacuo.

Workup

  1. customAt room temperature
  2. extractionextracted with dichloromethane
  3. washThe organic layer was washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-aa1ef4ba169543c8aedba9941498d743
Source dataset
uspto-grants-2013_03
Patent number
US08394789B2

Reaction notes

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