反应详情

A mixture of 5-benzenesulfonyl-2-methylsulfanylpyrimidine-4-carboxylic acid methyl ester (1.4 g) and tetrahydrofuran (20 mL) was treated with 1.0 M aqueous lithium hydroxide solution (2.2 mL), and the resulting mixture was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure, pH adjusted to 4 by the addition of 0.1 M aqueous hydrochloric acid solution and extracted with ethyl acetate. The combined extract was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated under reduced pressure to afford the title compound as a pale yellow solid (1.3 g).

1. concentrationThe mixture was concentrated under reduced pressure
2. additionpH adjusted to 4 by the addition of 0.1 M aqueous hydrochloric acid solution
3. extractionextracted with ethyl acetate
4. extractionThe combined extract
5. washwas washed with saturated aqueous sodium chloride solution
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated under reduced pressure