Piperazine → HCID 66815800, compound

HRID 1944540Notes

Reaction equation

HRID 1944540 reaction equation
F[C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]2[CH:10]=[N:11][C:12]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3)=[O:7])=[CH:4][CH:3]=1.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>CS(C)=O>[N:21]1([C:2]2[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]3[CH:10]=[N:11][C:12]4[C:17]([CH:18]=3)=[CH:16][CH:15]=[CH:14][CH:13]=4)=[O:7])=[CH:4][CH:3]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 18146450HCID 18146450, compound

Product 1

HCID 66815800HCID 66815800, compoundYield 202.4%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A solution of 4-fluoro-N-quinolin-3-yl-benzamide (2.0 g, 3.76 mmol) and piperazine (6.2 g, 72 mmol) in methylsulfoxide (30 mL) was heated 100° C. for 1.5 days, to give the product 2.53 g (100%).

Sources & evidence

ORD record
ord-a15389d660b848439029b184112863bc
Source dataset
uspto-grants-2013_03
Patent number
US08394828B2

Reaction notes

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