反应详情

温度

90 °C

Potassium carbonate (0.315 g) was added to a stirred solution of the product from step (i) (0.4 g) and ethyl-(4-bromo-phenyl)-sulfone (0.285 g) in NMP (10 ml) and the mixture heated at 90° C. for 1 h. The mixture was partitioned between water/ethylacetate, the organics separated, dried, and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 25% ethylacetate/isohexane. Yield 0.4 g

1. customThe mixture was partitioned between water/ethylacetate
2. customthe organics separated, dried
3. customevaporated under reduced pressure
4. customThe residue was purified by chromatography on silica eluting with 25% ethylacetate/isohexane