Methyl iodide → 3-Chloro-4-fluorophenyl methyl sulfide

HRID 1945199Notes

Reaction equation

HRID 1945199 reaction equation
IC.[Cl:3][C:4]1[CH:5]=[C:6]([SH:11])[CH:7]=[CH:8][C:9]=1[F:10].[C:12](=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[CH3:12][S:11][C:6]1[CH:7]=[CH:8][C:9]([F:10])=[C:4]([Cl:3])[CH:5]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27341973-Chloro-4-fluorobenzene-1-thiol

Product 1

HCID 552207093-Chloro-4-fluorophenyl methyl sulfide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

Iodomethane (1.15 ml) was added to a stirred mixture of 3-chloro-4-fluoro-benzenethiol (3.0 g), potassium carbonate (2.48 g) in DMF (20 ml) and left overnight. The reaction was diluted with water and extracted with diethylether, the organics were dried and evaporated under reduced pressure, yield 4.3 g.

Workup

  1. extractionextracted with diethylether
  2. customthe organics were dried
  3. customevaporated under reduced pressure, yield 4.3 g

Sources & evidence

ORD record
ord-bd6df2600fd5476da74a797be43d83f6
Source dataset
uspto-grants-2013_03
Patent number
US08394986B2

Reaction notes

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