Lithium Chloride → HCID 66995735, compound

HRID 1945208Notes

Reaction equation

HRID 1945208 reaction equation
[F:1][C:2]1[C:16]([F:17])=[CH:15][C:5]([O:6][CH2:7][C:8]([O:10]C(C)(C)C)=[O:9])=[C:4]([O:18]C)[CH:3]=1.[Cl-].[Li+]>CN(C=O)C>[F:1][C:2]1[C:16]([F:17])=[CH:15][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([OH:18])[CH:3]=1

Participants

4

Reactant 2

HCID 433294Lithium ChlorideHCID 86034419HCID 86034419, compound

Product 1

HCID 66995735HCID 66995735, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of the product from step (ii) (0.75 g) and lithium chloride (0.345 g) in DMF (20 ml) was heated at 150° C. for 6 h, cooled and partitioned between ethylacetate/2M hydrochloric acid. The organics were dried and evaporated under reduced pressure, yield 0.7 g.

Workup

  1. temperaturecooled
  2. custompartitioned between ethylacetate/2M hydrochloric acid
  3. customThe organics were dried
  4. customevaporated under reduced pressure, yield 0.7 g

Sources & evidence

ORD record
ord-af4b834a179b4de5a80f6345d4ef3f5e
Source dataset
uspto-grants-2013_03
Patent number
US08394986B2

Reaction notes

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