Dichloromethane → 2-(2-Bromo-4-chlorophenyl)-2-fluoroacetonitrile

HRID 194554Notes

Reaction equation

HRID 194554 reaction equation
[Br:1][c:2]1[c:3]([CH:4]=[O:5])[cH:6][cH:7][c:8]([Cl:10])[cH:9]1.[CH2:17]([N:18]([S:19]([F:20])([F:21])[F:23])[CH2:22][CH3:24])[CH3:25].[CH3:11][Si:12]([CH3:13])([CH3:14])[C:15]#[N:16].[Cl:26][CH2:27][Cl:28].[I-:29].[I-:31].[Zn+2:30]>>[Br:1][c:2]1[c:3]([CH:4]([C:15]#[N:16])[F:23])[cH:6][cH:7][c:8]([Cl:10])[cH:9]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 30165Iodide Ion2×HCID 32051Zinc(2+)HCID 82115Trimethylsilyl cyanideHCID 123472(Diethylamino)sulfur trifluorideHCID 131547102-Bromo-4-chlorobenzaldehyde

Product 1

HCID 574450602-(2-Bromo-4-chlorophenyl)-2-fluoroacetonitrile

Sources & evidence

ORD record
ord-51ddb8779803473587512eae99f6c9a7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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