Triethylamine → HCID 21949386, compound

HRID 1945739Notes

Reaction equation

HRID 1945739 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:10])([CH3:9])[CH3:8])[CH2:3][CH2:2]1.Cl[C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13].C(N(CC)CC)C>C(Cl)(Cl)Cl>[OH:10][C:7]([CH:4]1[CH2:5][CH2:6][N:1]([C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:13])[CH2:2][CH2:3]1)([CH3:9])[CH3:8]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10387Benzyl chloroformateHCID 52003212-(4-Piperidyl)-2-propanol

Product 1

HCID 21949386HCID 21949386, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-(Piperidin-4-yl)propan-2-ol (1 g) was reacted with 1.1 eq of benzyl chloroformate and 1.3 eq of triethylamine in 30 mL of chloroform. The reaction was halted after 2 days at room temperature and purified by isco (0-60% Hexanes/Ethyl Acetate over 20 minutes) to afford 1.49 g benzyl 4-(2-hydroxypropan-2-yl)piperidine-1-carboxylate.

Workup

  1. custompurified by isco (0-60% Hexanes/Ethyl Acetate over 20 minutes)

Sources & evidence

ORD record
ord-7c8c305ae51b4749b2b0f8a1fa6410be
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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