反应详情

To a solution of 2-chloro-6-{[(methyloxy)methyl]oxy}benzoic acid (for a preparation see Intermediate 4)(2 g, 9.23 mmol) in THF (20 ml) was added 6 M aqueous HCl (20 ml, 120 mmol). The solution was stirred at ambient temperature for 3 h. The solution was partitioned between ethyl acetate (150 ml) and water (30 ml). The phases were separated and the organic extract washed with water (25 ml). The organic extract was dried (MgSO4), filtered and the solvent removed in vacuo to give the title compound as a white solid (1.54 g); LCMS: (System 1) (M-H)−=171, tRET=3.26 min.

1. customThe solution was partitioned between ethyl acetate (150 ml) and water (30 ml)
2. customThe phases were separated
3. extractionthe organic extract
4. washwashed with water (25 ml)
5. extractionThe organic extract
6. dry with materialwas dried (MgSO4)
7. filtrationfiltered
8. customthe solvent removed in vacuo