反应详情

温度

50 °C

To a solution of crude 2-(1-{[2-(phenyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione (2.35 g, 5.94 mmol) in THF (30 ml) was added hydrazine hydrate (1.44 ml, 29.7 mmol, Aldrich). The resulting colourless solution was stirred at 50° C. for 2 h. A white solid precipitated. The suspension was cooled to ambient temperature and filtered through a sinter funnel. The filtrate was then filtered through a hydrophobic frit and concentrated under reduced pressure to give the title compound as a white solid (1.58 g); LCMS: (System 3) MH+=266, tRET=0.86 min.

1. customA white solid precipitated
2. temperatureThe suspension was cooled to ambient temperature
3. filtrationfiltered through a sinter funnel
4. filtrationThe filtrate was then filtered through a hydrophobic frit
5. concentrationconcentrated under reduced pressure