反应详情

To 10% palladium on carbon 50% wt water, degussa type E101 NE/W (406 mg, 3.82 mmol) was added under vacuum a solution of 2,6-difluoro-N-[1-({2-methyl-4-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]benzamide (for a preparation see Example 47)(1.79 g, 4.13 mmol) in ethyl acetate (30 ml). The suspension was hydrogenated at ambient temperature for 1.5 h. The suspension was filtered through a celite cartridge (10 g) and the cartridge washed with methanol (100 ml). The solvent was removed in vacuo to give the title compound as a grey foam (1.34 g);

1. filtrationThe suspension was filtered through a celite cartridge (10 g)
2. washthe cartridge washed with methanol (100 ml)
3. customThe solvent was removed in vacuo