Hydrochloric Acid → HCID 66790278, compound

HRID 1946411Notes

Reaction equation

HRID 1946411 reaction equation
[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([CH2:10][N:11]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([C:19]4[CH:24]=[CH:23][N:22]=[CH:21][C:20]=4[CH3:25])=[O:18])=[N:12]3)=[C:6]([C:26]([F:29])([F:28])[F:27])[CH:5]=2)[CH2:3][CH2:2]1.[ClH:30].O1CCOCC1>CO>[ClH:30].[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([CH2:10][N:11]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([C:19]4[CH:24]=[CH:23][N:22]=[CH:21][C:20]=4[CH3:25])=[O:18])=[N:12]3)=[C:6]([C:26]([F:27])([F:29])[F:28])[CH:5]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59547986HCID 59547986, compound

Product 1

HCID 66790278HCID 66790278, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To N-(1-{[4-cyclopropyl-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)-3-methyl-4-pyridinecarboxamide (for a preparation see Example 149)(20 mg) dissolved in methanol (1 ml) was added 4.0 M hydrochloride in 1,4-dioxane (0.4 ml, 1.60 mmol). The solvent was removed under a stream of nitrogen to give the title compound as an orange gum (38 mg); LCMS: (System 4) MH+=401, tRET=2.50 min.

Workup

  1. customThe solvent was removed under a stream of nitrogen

Sources & evidence

ORD record
ord-82d59f18a9ef4d6fa4265d141ac1c3ce
Source dataset
uspto-grants-2013_03
Patent number
US08399436B2

Reaction notes

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