反应详情

Title compound 354 (3.1 g, 11.8 mmol), sodium hydride (565 mg, 14.14 mmol) and methyliodide (0.88 mL, 14.14 mmol) were stirred together in DMF (60 mL) at room temperature for 6 hours. DMF was removed and the residue was partitioned in EtOAc and water. The organic layer was dried, filtered and evaporated. The crude product was purified by flash chromatography (3:1 to 1:2 hexane:ethyl acetate) to afford title compound 357 (2.3 g, 60%) as a white solid.

1. customDMF was removed
2. customthe residue was partitioned in EtOAc
3. customThe organic layer was dried
4. filtrationfiltered
5. customevaporated
6. customThe crude product was purified by flash chromatography (3:1 to 1:2 hexane:ethyl acetate)