4-Aminophenol → HCID 25182622, compound

HRID 1946705Notes

Reaction equation

HRID 1946705 reaction equation
[CH:1]1([CH2:7][NH:8][C:9]2[N:14]=[CH:13][N:12]=[C:11]([C:15]([OH:17])=O)[CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1>CCOC(C)=O>[CH:1]1([CH2:7][NH:8][C:9]2[N:14]=[CH:13][N:12]=[C:11]([C:15]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=3)=[O:17])[CH:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 4034-AminophenolHCID 59446935HCID 59446935, compound2×

Product 1

HCID 25182622HCID 25182622, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-[(cyclohexylmethyl)amino]pyrimidine-4-carboxylic acid (Intermediate 6) and 4-amino-phenol (Aldrich), the title compound was obtained as a white solid after trituration in EtOAc.

Sources & evidence

ORD record
ord-8b2c80378d4441bb8b44fd7e84b52c29
Source dataset
uspto-grants-2013_03
Patent number
US08399448B2

Reaction notes

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