Dimethylformamide → 2,2-difluoro-N-(2-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-4-morpholinopyrido[3,2-d]pyrimidin-2-ylamino)phenyl)propanamide

HRID 194690Notes

Reaction equation

HRID 194690 reaction equation
[CH:67]([N:68]([CH2:69][CH3:70])[CH:71]([CH3:72])[CH3:73])([CH3:74])[CH3:75].[F:36][C:37]([C:38](=[O:39])[OH:40])([CH3:41])[F:42].[F:43][P-:44]([F:45])([F:46])([F:47])([F:48])[F:49].[NH2:1][c:2]1[c:3]([NH:8][c:9]2[n:10][c:11]([N:30]3[CH2:31][CH2:32][O:33][CH2:34][CH2:35]3)[c:12]3[c:13]([n:14]2)[cH:15][cH:16][c:17]([CH2:19][N:20]2[CH2:21][CH2:22][CH:23]([C:26]([CH3:27])([CH3:28])[OH:29])[CH2:24][CH2:25]2)[n:18]3)[cH:4][cH:5][cH:6][cH:7]1.[O:76]=[CH:77][N:78]([CH3:79])[CH3:80].[n:50]1([O:51][C:52]([N:53]([CH3:54])[CH3:55])=[N+:56]([CH3:57])[CH3:58])[c:59]2[n:60][cH:61][cH:62][cH:63][c:64]2[n:65][n:66]1>>[NH:1]([c:2]1[c:3]([NH:8][c:9]2[n:10][c:11]([N:30]3[CH2:31][CH2:32][O:33][CH2:34][CH2:35]3)[c:12]3[c:13]([n:14]2)[cH:15][cH:16][c:17]([CH2:19][N:20]2[CH2:21][CH2:22][CH:23]([C:26]([CH3:27])([CH3:28])[OH:29])[CH2:24][CH2:25]2)[n:18]3)[cH:4][cH:5][cH:6][cH:7]1)[C:38]([C:37]([F:36])([CH3:41])[F:42])=[O:39]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 27828252,2-Difluoropropionic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 584049712-(1-((2-(2-Aminophenylamino)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol

Product 1

HCID 584050242,2-difluoro-N-(2-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-4-morpholinopyrido[3,2-d]pyrimidin-2-ylamino)phenyl)propanamide

Sources & evidence

ORD record
ord-b4e89b0a0c824079b8f9db62af9a2cb4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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