Hydrochloric Acid → HCID 178478138, compound

HRID 1946975Notes

Reaction equation

HRID 1946975 reaction equation
[CH2:1]([NH:8][C:9]1[N:10]=[CH:11][N:12](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>O1CCOCC1>[ClH:33].[CH2:1]([NH:8][C:9]1[N:10]=[CH:11][NH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59742752HCID 59742752, compound

Product 1

HCID 178478138HCID 178478138, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Benzyl-(1-trityl-1H-imidazol-4-yl)-amine (0.15 g, 0.35 mmol) was dissolved in a 4 M solution of HCl in dioxane (5 ml). The mixture was stirred at room temperature for 90 minutes and then concentrated in vacuo. The residue was triturated in ether to yield the title compound as an off-white solid (73 mg, 100%); MS (ISP): 174.4 ([M+H]+).

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was triturated in ether

Sources & evidence

ORD record
ord-de44f4eb61874aa3922103312d467725
Source dataset
uspto-grants-2013_03
Patent number
US08399463B2

Reaction notes

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