Hydrogen chloride-ethyl acetate → HCID 66893209, compound

HRID 1947128Notes

Reaction equation

HRID 1947128 reaction equation
[CH3:1][O:2][C:3]1[C:7]2[C:8](=[O:25])[N:9]([CH2:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[S:5][C:4]=1[C:26]([N:28]([CH3:39])[CH2:29][CH2:30][NH:31]C(=O)OC(C)(C)C)=[O:27].C(OC(=O)C)C.[ClH:46]>C(OCC)(=O)C>[ClH:46].[NH2:31][CH2:30][CH2:29][N:28]([CH3:39])[C:26]([C:4]1[S:5][C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]([CH2:16][C:17](=[O:24])[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:8](=[O:25])[C:7]=2[C:3]=1[O:2][CH3:1])=[O:27]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86634219HCID 86634219, compound

Product 1

HCID 66893209HCID 66893209, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of the obtained tert-butyl {2-[{[3-methoxy-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydrothieno[3,2-c]quinolin-2-yl]carbonyl}(methyl)amino]ethyl}carbamate (230 mg) and 4N hydrogen chloride ethyl acetate solution (8 mL) in ethyl acetate (15 mL) was stirred at room temperature for 2 hr. The obtained precipitate was collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the title compound (178 mg, 48%) as a white powder.

Workup

  1. filtrationThe obtained precipitate was collected by filtration
  2. washwashed with diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-39a6dafd196f4c7981559498d4861fd7
Source dataset
uspto-grants-2013_03
Patent number
US08399449B2

Reaction notes

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