Hydrazine hydrate (1:1) → HCID 178458730, compound

HRID 1947203Notes

Reaction equation

HRID 1947203 reaction equation
[CH2:1]([O:4][C:5]1[CH:26]=[C:25]([O:27][CH2:28][CH:29]=[CH2:30])[C:24]([CH2:31][C:32]#[C:33][CH3:34])=[CH:23][C:6]=1[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13](CN2CCOCC2)=[CH:12][CH:11]=1)=S)[CH:2]=[CH2:3].[OH2:35].[NH2:36][NH2:37]>C(O)C>[CH2:1]([O:4][C:5]1[CH:26]=[C:25]([O:27][CH2:28][CH:29]=[CH2:30])[C:24]([CH2:31][C:32]#[C:33][CH3:34])=[CH:23][C:6]=1[C:7](=[N:36][NH2:37])[NH:9][C:10]1[CH:11]=[CH:12][C:13]([N:9]2[CH2:10][CH2:11][O:35][CH2:6][CH2:7]2)=[CH:14][CH:15]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59829873HCID 59829873, compound

Product 1

HCID 178458730HCID 178458730, compoundYield 122.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Crude 2,4-bis-allyloxy 5-(but-2-ynyl)-N-[4-(morpholin-4-ylmethyl)-phenyl]-thiobenzamide (F470-IM10: 240 mg, 0.86 mmol) and hydrazine monohydrate (700 mg, 14 mmol) were dissolved in ethanol (6 mL) and the mixture was heated under reflux for 1 hour and then concentrated to obtain the crude title compound (F470-IM11: 243 mg).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1 hour
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-8c64933088bb40b187438f0afcd5aba7
Source dataset
uspto-grants-2013_03
Patent number
US08399464B2

Reaction notes

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