Hydrochloric Acid → 2-Chloro-4-(4-(methylsulfonyl)piperazin-1-yl)furo[3,2-d]pyrimidine

HRID 194738Notes

Reaction equation

HRID 194738 reaction equation
[CH2:29]1[NH:30][CH2:31][CH2:32][NH:33][CH2:34]1.[CH3:35][S:36]([Cl:37])(=[O:38])=[O:39].[Cl:18][c:19]1[n:20][c:21]([Cl:22])[c:23]2[o:24][cH:25][cH:26][c:27]2[n:28]1.[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][o:10]2.[Cl:46][CH2:47][Cl:48].[ClH:17].[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1>>[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH2:13][N:14]([S:36]([CH3:35])(=[O:38])=[O:39])[CH2:15][CH2:16]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][o:10]2

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 4837PiperazineHCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 457899682,4-Dichlorofuro[3,2-D]pyrimidineHCID 866650962-Chloro-4-piperazin-1-ylfuro[3,2-d]pyrimidine

Product 1

HCID 866650952-Chloro-4-(4-(methylsulfonyl)piperazin-1-yl)furo[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-92bd77577b444c95ba9ec8c202d10946
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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