Hydrochloric Acid → N-(2-iodo-4-nitrophenyl)methanesulfonamide

HRID 1947436노트

반응식

HRID 1947436 반응식
[Li+].[OH-].[I:3][C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[N:13](S(C)(=O)=O)[S:14]([CH3:17])(=[O:16])=[O:15].[NH4+].[Cl-].Cl>C(O)C.O.C(O)C.O>[I:3][C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[NH:13][S:14]([CH3:17])(=[O:16])=[O:15]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 25517Ammonium ChlorideHCID 67284344N-(2-iodo-4-nitrophenyl)-N-(methylsulfonyl)methanesulfonamide

생성물 1

HCID 67284366N-(2-iodo-4-nitrophenyl)methanesulfonamide

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매HCID 19096565Water ethanol용매

실험 절차

LiOH (0.21 mg, 8.9 mmol) in a mixture ethanol/water 2/1 (18 ml) was added to a solution of N-(2-iodo-4-nitrophenyl)-N-(methylsulfonyl)methanesulfonamide (0.75 g, 1.78 mmol). The reaction mixture was refluxed for two hours. After cooling at room temperature, the reaction mixture was neutralized with H2O, NH4Cl and HCl 2N, then ethanol was eliminated, and the aqueous phase was extracted with ethyl acetate (3×20 ml). The organic solvent was removed by evaporating under reduced pressure to give N-(2-iodo-4-nitrophenyl)methanesulfonamide without further purification.

후처리

  1. temperatureThe reaction mixture was refluxed for two hours
  2. extractionthe aqueous phase was extracted with ethyl acetate (3×20 ml)
  3. customThe organic solvent was removed
  4. customby evaporating under reduced pressure

출처 및 근거

ORD 기록
ord-61b7305d9e524453a2110bd581ffadd9
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399477B2

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