Acetic Acid → HCID 1485634, compound

HRID 1947441Notes

Reaction equation

HRID 1947441 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[N:9]([CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[N:13]=2)[CH:10]=1)=[O:4].C(O)(=O)C>Br>[F:20][C:17]1[CH:16]=[CH:15][C:14]([C:12]2[N:13]=[C:8]3[CH:7]=[CH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:10][N:9]3[CH:11]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 1485603HCID 1485603, compound

Product 1

HCID 1485634HCID 1485634, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

2-(4-Fluoro-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (example 1; 590 mg, 2.18 mmol) was heated in 5 ml hydrobromic acid (48%) and 15 ml acetic acid at 120° C. for 10 hours. The solid was filtered, washed and dried. Yield: 38%. MS: M+H+=257.04.

Workup

  1. filtrationThe solid was filtered
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-d094ded1b3f6488ba8b9cbd0ca399b6e
Source dataset
uspto-grants-2013_03
Patent number
US08399476B2

Reaction notes

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