Hydrochloric Acid → HCID 66786500, compound

HRID 1947508Notes

Reaction equation

HRID 1947508 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[C:13]2[CH:14]=[CH:15][C:16]([O:18][C:19]3[S:20][C:21]4[C:22]([N:27]=3)=[N:23][CH:24]=[CH:25][CH:26]=4)=[CH:17][C:12]=2[O:11][CH:10]=1)(C)(C)C.[ClH:29]>C(Cl)Cl.C(OCC)C>[ClH:29].[S:20]1[C:21]2[C:22](=[N:23][CH:24]=[CH:25][CH:26]=2)[N:27]=[C:19]1[O:18][C:16]1[CH:15]=[CH:14][C:13]2[C:9]([CH2:8][NH2:7])=[CH:10][O:11][C:12]=2[CH:17]=1

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 59577389HCID 59577389, compound

Product 1

HCID 66786500HCID 66786500, compoundYield 130%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 2 [6-(thiazolo[4,5-b]pyridin-2-yloxy)-benzofuran-3-ylmethyl]-carbamic acid tert-butyl ester (0.10 g, 0.25 mmol) in DCM (1.2 mL) was added 2 M HCl in diethyl ether (0.38 mL). The reaction was stirred (rt, 16 h) before additional HCl (0.38 mL) was added. The reaction was stirred (rt, 24 h) and concentrated to provide the title compound as a white solid (98 mg, 130%). Additional mass is likely due to retained HCl and/or solvent. MS (ESI): mass calcd. for C15H11N3O2S, 297.06; m/z found, 298.1 [M+H]+.

Workup

  1. additionwas added
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-d3436316f7bb4c96b505b55c4de4be76
Source dataset
uspto-grants-2013_03
Patent number
US08399465B2

Reaction notes

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