反应详情

A solution of 6-amino-7-cyanoindan-1-ol (700 mg, 4 mmol) in tetrahydrofuran (50 ml) is treated with N-chlorosuccinimide (530 mg, 4 mmol) in portions over 20 minutes, stirred for 30 minutes, treated with sodiumborohydride (270 mg), and stirred for one hour. The mixture is quenched with water (30 ml), evaporated to remove tetrahydrofuran, and extracted with ethyl acetate. The organic layer is dried over sodium sulfate, filtered, and evaporated to give 6-amino-5-chloro-7-cyanoindan-1-ol (400 mg) which is directly used in the next step; LC/MS: 209/211 (M+1)+.

1. stirringstirred for one hour
2. customThe mixture is quenched with water (30 ml)
3. customevaporated
4. customto remove tetrahydrofuran
5. extractionextracted with ethyl acetate
6. dry with materialThe organic layer is dried over sodium sulfate
7. filtrationfiltered
8. customevaporated