Trifluoroacetic acid → 7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

HRID 1947889Notes

Reaction equation

HRID 1947889 reaction equation
C(OC([NH:8][C:9]1[C:17]2[C:16](=[O:18])[N:15]([CH3:19])[CH2:14][C:13]=2[C:12]([C:20]([OH:22])=[O:21])=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:8][C:9]1[C:17]2[C:16](=[O:18])[N:15]([CH3:19])[CH2:14][C:13]=2[C:12]([C:20]([OH:22])=[O:21])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 672564057-[(Tert-butoxycarbonyl)amino]-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Product 1

HCID 672542797-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Procedure

The title compound was prepared by deprotecting Compound 116C with TFA. The crude product was taken on to the next step without purification.

Workup

  1. customThe crude product was taken on to the next step without purification

Sources & evidence

ORD record
ord-b0aba7bb9d2343b3939ab5a3f0f58a1b
Source dataset
uspto-grants-2013_03
Patent number
US08399433B2

Reaction notes

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