Hydrochloric Acid → 4-(1-Amino-2-fluoro-ethyl)-4-ethyl-cyclohexanol

HRID 1948151Notes

Reaction equation

HRID 1948151 reaction equation
Cl.[NH2:2][CH:3]([C:8]1([CH2:15][CH:16]2CC2)[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)[C:4](F)(F)[F:5]>>[NH2:2][CH:3]([C:8]1([CH2:15][CH3:16])[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)[CH2:4][F:5]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 670729054-(1-Amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol

Product 1

HCID 583808384-(1-Amino-2-fluoro-ethyl)-4-ethyl-cyclohexanol

Procedure

99 mg of 55 were synthesized as mixture of stereoisomers as its hydrochloride from 236 mg (704 μmol) of 53 using the protocol described for the synthesis of compound 21. Rt=0.09, 0.14 min (Method P). Detected mass: 190.3 ([M+H+).

Workup

  1. customRt=0.09, 0.14 min (Method P)

Sources & evidence

ORD record
ord-88338d938c9848f2b5c96a474f9d042d
Source dataset
uspto-grants-2013_03
Patent number
US08399482B2

Reaction notes

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