Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 86648557, compound

HRID 1948384Notes

Reaction equation

HRID 1948384 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]([N:28]=[N+:29]=[N-:30])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CC1C=CC(S([O-])(=O)=O)=CC=1.C1C=C[NH+]=CC=1>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C@H:11]([NH2:14])[C@H:10]([N:28]=[N+:29]=[N-:30])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 90902601HCID 90902601, compound2×

Product 1

HCID 86648557HCID 86648557, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

tert-butyl-3-azido-4-[(diphenylmethylene)amino]piperidine-1-carboxylate (Intermediate 269, 1.36 g; 3.3 mmol) was dissolved in 10 ml's of aqueous THF (5% H2O). PPTS (850 mg; 3.4 mmol; 1.03 eq.) was added in a single portion. The initial cloudy solution became clear within minutes. Upon completion (as determined by LC/MS analysis) the reaction was concentrated and azeotropically dried with acetonitrile. No further purification. (LC/MS: see disappearance of starting material and formation of Ph2C═O. Product is not observable due to lack of chromophore).

Workup

  1. waitThe initial cloudy solution became clear within minutes
  2. concentrationUpon completion (as determined by LC/MS analysis) the reaction was concentrated
  3. dry with materialazeotropically dried with acetonitrile
  4. customNo further purification

Sources & evidence

ORD record
ord-23eaea4916654d999e71f56ccad89b7b
Source dataset
uspto-grants-2013_03
Patent number
US08399489B2

Reaction notes

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