反应详情

温度

60 °C

A mixture of 3-phenylbutanal (Trifernal®, 0.67 g, 4.5 mmol), glycinamide hydrochloride (0.50 g, 4.5 mmol), triethylamine (0.46 g, 4.5 mmol) and K2CO3 in ethanol (4 ml) was heated to 60° C. for 24 h. Then the solvent was removed under vacuum at 40° C. The residue was taken up in ether and the solvent evaporated to yield 0.52 g (57%) of a highly viscous oil as a mixture of diastereoisomers.

1. customThen the solvent was removed under vacuum at 40° C
2. customthe solvent evaporated
3. customto yield 0.52 g (57%) of a highly viscous oil
4. additionas a mixture of diastereoisomers