Pyrrolidine → HCID 57475112, compound

HRID 1948615Notes

Reaction equation

HRID 1948615 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:6]1[CH:10]=[CH:9][N:8]=[N:7]1.[O:11]1[C:15]2([CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[N:1]1([C:18]2([N:6]3[CH:10]=[CH:9][N:8]=[N:7]3)[CH2:19][CH2:20][C:15]3([O:14][CH2:13][CH2:12][O:11]3)[CH2:16][CH2:17]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 31268PyrrolidineHCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 178418936HCID 178418936, compound

Product 1

HCID 57475112HCID 57475112, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
90 °C

Procedure

Pyrrolidine (1.95 g, 2.29 ml, 27.5 mmole), 1,2,3-triazole (2.07 g, 30 mmole) and molecular sieve 4 Å (7.14 g) were added to a solution of 1,4-dioxaspiro[4,5]decan-8-one (3.9 g, 25 mmole) in toluene (40 ml). The mixture was stirred for 7 days at 90° C. The solution was then decanted and immediately reacted further.

Workup

  1. customThe solution was then decanted
  2. customimmediately reacted further

Sources & evidence

ORD record
ord-d80cecc52be04fd6993edf15c2c674e0
Source dataset
uspto-grants-2013_03
Patent number
US08399503B2

Reaction notes

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