Acetic Acid → HCID 75985013, compound

HRID 1948984Notes

Reaction equation

HRID 1948984 reaction equation
Br[CH2:2][C:3]([O:11][CH3:12])=[CH:4][C:5](=[O:10])[C:6]([Cl:9])([Cl:8])[Cl:7].[C:13]([O-:16])(=[O:15])[CH3:14].[K+].C(O)(=O)C>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(#N)C>[C:13]([O:16][CH2:2][C:3]([O:11][CH3:12])=[CH:4][C:5](=[O:10])[C:6]([Cl:9])([Cl:8])[Cl:7])(=[O:15])[CH3:14]

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 517044Potassium AcetateHCID 72820289HCID 72820289, compound

Product 1

HCID 75985013HCID 75985013, compound

Reagents, catalysts & solvents 2

HCID 74236Tetrabutylammonium BromideCatalystHCID 6342AcetonitrileSolvent

Procedure

29.6 g (0.1 mol) of 5-bromo-1,1,1-trichloro-4-methoxypent-3-en-2-one, 17 g of potassium acetate, 5 g of tetrabutylammonium bromide and 8 g of acetic acid were stirred at 40° C. in 300 ml of acetonitrile for 16 h. The mixture was concentrated under reduced pressure, and the water was added to the residue. The product was extracted with ethyl acetate, the organic phase was washed with water and the solvent was removed completely under reduced pressure.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionthe water was added to the residue
  3. extractionThe product was extracted with ethyl acetate
  4. washthe organic phase was washed with water
  5. customthe solvent was removed completely under reduced pressure

Sources & evidence

ORD record
ord-461bd05d96ae44498cb10850eab5f871
Source dataset
uspto-grants-2013_03
Patent number
US08399679B2

Reaction notes

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